| Pair Name | Zerumbone, Celecoxib | ||
| Phytochemical Name | Zerumbone (PubChem CID: 5470187 ) | ||
| Anticancer drug Name | Celecoxib (PubChem CID: 2662 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Zerumbone, Celecoxib | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF3 | hsa467 |
| Up-regulation | Expression | ATF4 | hsa468 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Phosphorylation | EIF2AK3 | hsa9451 | |
| Up-regulation | Phosphorylation | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Our results provide novel insights into the role of ATF3 as an essential transcription factor for p53-independent DR5 induction upon both ZER and CCB treatment, and this may be a useful biomarker for TRAIL-based anticancer therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J Biol Chem. 2014 Aug 1;289(31):21544-61. doi: 10.1074/jbc.M114.558890. | Click |
